Here we found that a hypomorphic allele of isoprenylcysteine carboxyl. Methylation of the remain ing terminal cysteine is carried out by isoprenyl cysteine carbo xyl meth yltransferase icmt and a final clipping of the protein by zmp ste24 to generate mature lamin a. The mature lamin a is approximately 2 kda less than prelamin a agarwal et al 2003.
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